I have used the
pdflrf program to process the pdf file for the Sony Reader.
I have just run a linux (well, FreeBSD ;-) ) command
./pdflrflinux-0.99 --input=infected_novel.pdf --output=infected_novel.pdf.lrf
and the result stunned me beyond belief.
Holy $DEITY !
pdfrlf has produced absolutely unbelievable results just with out-of-the-box settings.