Let's see, I spun this up a few months back, if it helps.
I'm finding that I'm having to think about font selection/design more along the lines what would look good on paper, rather than on lcd screen, at least, to accommodate the epaper readers, since machine-specific-conditional-formatting doesn't seem to be there for epub, much as we would want it to be.
When we're talking about printing books on paper, Minion has been the most popular choice for the last lots-of-years running, so it makes a degree of sense that overall readability quotients for epaper should have some parallel to that - I saw some post of what the epaper display looks like under a microscope, and it looked a lot like what ink on paper looked like, albeit at a lower resolution than what the best typographically-wrought pages come in at.
I'm finding that different books have different characteristics as to how I feel reading them, i.e., horror is different than poetry which is different to science etc., and different font combinations change how some of those impressions work, just like on paper.
Even if it's more work than I really care to throw at it at times, I can't really say "oh yes, this is the font for me for all possible circumstances no matter what", 'cause I keep changing my mind as to what looks good. The experience of reading is more complex than word-flow and using the same font set no matter what.
-b
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