With reference to a complicated tax schedule, I think that would only affect small online retailers operating out of California who will now be forced to collect tax. Large enterprises obviously have the software already in operation.
Barnes & Noble, for instance, applies my county's 8.25% sales tax rate to my NookBook purchases instantaneously, once I hit the "Order" button.
It amuses me that they always list the "Shipping & Handling" charge as FREE (instead of N/A, which I think would be more appropriate) since they're supplying the purchase electronically