My first reader was the Nook Classic, then Kindle3 & finally the Sony 350. So I can only compare the 6" to the 5". I definitely prefer my Sony 350 because I find the size & weight comfortable to read with. Both the Kindle & Nook Classic feel heavy & awkward to read with when I'm reading for any amount of time. Plus I don't like large purses, so toting my 350 around is perfect for my purse size.
I never would have noticed the Nook & Kindle being heavy or awkward though if I hadn't gotten a Sony 350.
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