I agree with RealAct. Disabling touchscreen page navigation would be a nice option, maybe even disabling all the touchy stuff with an easily accessed toggle (e.g. touch and hold in a corner of the screen). It would be similar to orientation lock on a tablet device that would otherwise automatically change orientation. Once you are into reading mode, all you need are the physical page nav buttons and Home button (which would restore touchability to the UI).
Accidental page turns are a regular 'feature' when reading on my iPod Touch, but there's no reason Nook Touch can't do better, given it has dedicated page turn buttons.
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