I'm running the Nook STR with Launcher Pro, Dropbox, Kindle, FBReader, Softkeys, K-9 Mail and Dolphin HD Browser. They all work fine, but the both Dolphin and the built-in Broswer give up the ghost on some pages.
Quickoffice HD and Pulse News would not run properly. Documents to Go Viewer, on the other hand, works fine as far as I tested it.
As a general matter, the Nook STR runs as a respectable Android 2.1 tablet for programs whose screens are don't change too constantly.
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