I'm guessing you have a newer MBP with Snow Leopard. I would follow the tip that sonyreaderfan posted to boot in 32-bit mode. Then Sony Reader Library should be able to recognize the device by USB. It's a pain, but it's also the only solution I've seen posted that works for people. Also Adobe Digital Editions for Mac will not recognize the Sony ereaders regardless of what system you are using. Adobe has no plans to address this issue. Therefore, I use Reader Library to open DRM'ed ebooks and transfer them on my MBP.
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