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I think the ergonomics of any device is going to be highly individual. My 70 year old mother loves her Kindle DXG, so much so that when she lost her first one she told me that she really missed it so I bought her another. She does not find it heavy or clunky and reads with it in an MEdge cover. She plays golf occassionally and walks alot but does 0 push ups, sit ups, and curls each day. (winks)I got her her first DX when she was undergoing radiation and chemo for lung cancer and she never complained about the weight.
I have no doubt that different color fonts and backgrounds could be very helpful. Is that something that could be tested on a computer and see if it helps you Mom? If it does, then maybe you want a device with an LCD screen after all.
The nice thing about the Kindles is that they come with a 30 day trial period. You can get her a DXG and see if it works for her and she is comfortable with it. If she is not, you can return it for a full refund.
The other nice thing about the Kindles is Text to Speech. This will make her life easier if she does get to the point that she cannot read. It will increase the number of books that she can listen to. The one problem with the DXG is that it does not have the audible menus like the K3.
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