ProfElm,
I tried to use Calibre to organize articles used in our publications but it was too time consuming as every article had to be entered manually. However, it has now evolved and includes significantly more opportunities for customization.
What would be of incredible value would be a plugin (similar to ISBN) that reads the first page of the article and picks out the the relevant information (tile, authors, Journal, etc.) and then gathers the metadata from pub med or other similar sites and populates custom columns.
Then a simple way to export selected articles in various publication outputs (APA, MLA, etc) in appropriate format. Sorry Kovid, but going through the steps to create a catalog would be way too complicated for many people. It is surprising how many of my colleagues are computer illiterate.
Another issue for academic settings - the lack of ability to independently download and install programs. For us, that privilege was lost when the OR computers were all taken over by a celebrity sex tape.
Best of luck on your project!
Of course, this probably impossible.....but I like to dream