I love Calibre. I've been using it for my B&N Nook and Android phone. And now I'm using it on my Edge. Works AWESOME!!

I use Calibre to load the local newspaper right onto the Edge and off I go.

As far as the system working, Calibre picked up the Edge right away. I did need to Mount the Edge on the computer and then add the books into the library since Calbire drops the stuff into the download directory on the Edge. But these are little things.