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1. How good an A4 sized scientific journal article (elsevier/sciencedirect) looks on 10.1" Edge ?
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Part of how well an A4 pdf document will look on the Edge will depend on how it was created. Meaning, it depends on the font size used in the pdf, as well as, the margin spaces, etc. Some work better than others. It seems a lot of scientic pdfs are created with columnar text, and based on what I've heard from others, these can be a little more problematic. When some of the others on the forum are in their daylight hours, I'm sure they will provide you with some excellent information on this.
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Say, with the best scaling option, is it possible to read through one page completely without a need for zoom or scroll ?
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Part of this is answered above, re font and margin size in pdf. What I do is find the best zoom level to display the text and allow me adequate annotation room and work from there. That way I don't need to be continually scrolling and zooming. There are, however, some cases where this does not work... it depends on how good your eyes are, I suppose
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Can we annote in landscape+portrait on same pdf?
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Landscape (on the ereader side) is not supported, at this time, but is the most requested new feature. Entourage is working on it.