I'm at a loss to find the research on Google, but according to the impeccable credentials of "something I read somewhere," skipping an unknown word can distract for the next page or two, leading to wandering attention, re-reading, and/or poor comprehension. While I have not yet used the dictionary function in any of my reading apps, having the means at hand to immediately look up unfamiliar words can actually prevent greater distraction and aid immersion in the long run.
It can't hurt one's vocabulary, either.
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