I have played around and read 1/3 of a book on my new Nook. I have not had any ghosting issues or any issues for that matter.
I am very impressed with how responsive the screen is. I initially thought I wanted to use the buttons to change pages. I have an iPad that I use a lot to read on, and I get tired of swiping to turn pages.
I loved the fact I could pick this new Nook up and not have it change pages because my fingers happen to be near the page turn buttons. You actually have to press the button to turn the pages. Yet, it was simple enough to press the button. I found or rather it appeared to me, that the pages seemed to turn quicker with just a tap on the screen rather than using the button. I also like the fact I was able to change which buttons I wanted to be on top or bottom for the page turns:
I have not tried a PDF book yet as I try to use epub or mobi as a general rule.
I have made folders to organize my library and it was very simple to do. They are easy to access also.
I have been using the original Nook and this new one is so much smaller. It feels wonderful to hold.
All in all, after a few hours using it, I like it. It's very easy to use and straight forward.