Ok, I have deleted your other two posts. Even posting on two threads is one too many. Why would I want to have to deal with two discussions on the same topic, and confused users having to look at multiple threads for repeated answers?
That you say you had this issue after upgrading Calibre and not after upgrading specific plugins indicates that it is a generic issue. You raised a ticket which is the right thing to do in this situation. I have responded on your ticket - which is to say that I have no such problem with shortcuts with the latest release, they are all working fine on my plugins. Any further discussion on this should remain on that ticket.