Well, good news, myself! Calibre was the answer. (As to be expected.)
I ran the offending book through Calibre, changing nothing and saving as ePub again -> the font changed (no big loss) and everything was fast suddenly. Chapter turns, loading the book, resizing, the works.
Apparently Calibre inserted a lot of the CSS into the files themselves and rearranged the statements. I didn't really check to be honest, just a quick glance.
I'm just glad it works now.
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