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1024x600 tablets like the iPads and Nook Color do a reasonable job with full page PDFs, but a tablet with only 800x480 is going to have problems.
My Netbook is also 1024x600, and I find that if I hold it vertically (like a real book) in portrait mode, it also does a nice job with full page PDFs.
My Sony PRS-650 has a slightly lower 800x600 screen resolution, and a physically smaller screen, and together these two factors make viewing PDFs full screen much more difficult.
On the Sony, the best option seems to be to turn the PRS-650 by ninety degrees, in order to put the wider screen axis horizontal, then view standard portrait mode PDFs about a half page at a time. In this orientation, text is still pretty small, but I can read it fairly clearly without too many problems.
So, with only 800x480 resolution available, you will have to zoom in to read clearly, and I wouldn't count on being able to get more than about 1/3 to 1/2 of a PDF page on screen at a time.
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