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No AV software would EVER do a write lock on a file. Sorry, this can't be the cause.
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While the write lock may or may not be the issue ( lets not get into what bugs programs may have ...), going out on a real limb (especially with my memory), it was a read lock preventing deleting the old file and recreating the new backup file.
This was the one (and only) reproducible cause for the problems in creating the backup manifest file I remember for this bug that we had found, before I left Adobe, and it was definitely a conflict with AV software - (Kapersky or ClamAV - but there my memory is definitely sketchy).