I have never used (or even seen) InDesign, so this is probably more wishful thinking than useful advice. Ideally, you would export/convert the book to XHTML or ePUB, and then you'd just need to edit the CSS stylesheets and convert inline styling into classes et al. Some complex formatting (tables, sidenotes, etc.) might need more tweaking. That is assuming InDesign does not create the sort of HTML generated by MS-Word, of course.
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