Had the same phenomenon yesterday with my 350. Solved it by restarting the PC and using another USB port. Sounds for me like a problem caused by the operating system not by the reader.
Do you use WIN XP? Not recognizing an USB device is quite common at least on my hardware. Normally the problem is to solve like this:
Plug in the reader.
Open the hardware manager.
Search for yellow question marks there.
If there are any right klick with the mouse on in and remove it from the system.
Unplug an plug the reader. That often solves the problem.
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