IMO, The 350 is the best of the 300 and 600 combined in one package.
Small form factor, sharp screen, quick page turns, touch interface, with a fair sized chunk of memory. The new touchscreen is optical and embedded in the bezel, so no clarity lost. It has the same processor as the 650, so it pulls up pages fast (no more need to pre-turn pages). The touch interface is a mixed bag -- it'll all depend on your preference, but most people land between "prefer" and "tolerate".
The only thing the previous models (300 & 600) have that it lacks are more buttons, larger screen (trade off for small form), audio ports and expansion slots.
If you like your 300, there's little reason you won't love the 350. The question remains: will you like it $120 more than your 300? How much do you value more memory with a speedy touchscreen?
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