I've read a number of very good books, thought provoking and so forth, that were so disturbing to my world view that I'm surprised I made it through some of them. In a few cases I didn't make it through them.
"Hannibal" (Hannibal Lecter)... I hit the "dinner scene" and that was it for me.
"Lucifer's Hammer" took me several long breaks the first time I read it because I was so involved with the characters that I started to get really depressed over their situation(s).
I also once read an anthology of short stories of religiously themed science fiction which did an astounding job of challenging some assumptions I was living under at the time.
One (story not book) that I did make it through and that I still love, and that haunts me to this day, is the seminal work by Mr. Keyes, "Flowers for Algernon".
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