I've used the eCO system. It's relatively easy to use, saves a lot of time, and if your doc is a digital file, uploading beats stuffing pages into a think envelope and a few dollars' postage.
I've only used it for new and original works, myself. I've never gone back and republished them, say, as a print work... but unless the body of the work was changed, you don't have to re-register a new format.
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