ProfCash is right that you're not going to find a reader that is capable of handling both .mobi and ePub. I'm assuming that these files are DRM free, so that you can convert them? If that's the case Calibre does a nice job converting from one format to another, organizing books, and transferring them to the reader.
After screen quality, turning the page is the biggest consideration for me, considering that it is something that you will do hundreds of times in a book. I have arthritic wrists, so the big buttons of the Kindle and the Nook don't work for me. Also, I like a smaller reader; the big keyboard on the Kindle and the big LCD space on the Nook both add unnecessary size.
It's important to realize that while we all have our own opinions, that doesn't make any of us right or wrong. I like touchscreens and don't care about 3G. There are others who feel equally strongly against touchscreens and for 3G. The key is for you to look at all of our advice and decide what's most important for you.
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