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The registry entries are irrelevant- Calibre, due to its multi-OS scope, doesn't save anything in the registry, but rather in its configuration directory. You could try deleting that (save a copy first, if you want to)- you can find it via preferences->advanced->miscellaneous->open calibre config directory
Also, I've noticed that this is all on Win7, 64 bit, so you could try using some sort of 32bit mode, if there is such a thing available.
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