There are no registry entries for Calibre, the FAQ covers all the files that need to be moved and will retain all your settings.
If you have exactly the same installation paths (and operating system) on your laptop and desktop i.e. the local configuration folder for Calibre where your settings and plugins are stored is the same, then you will not have to reinstall your plugins.
However if those paths differ (e.g. different user name, OS, drive letter etc), then you will need to reinstall the plugins. However if you have copied across the plugins folder then all your settings for those plugins in the various .json files will be preserved.
Note for plugins I am referring to "end user" plugins, like you can get from the forums here, not the ones built into Calibre which will be fine.
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