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PDF is a bad format for text based books as it does not allow for text reflow and thus the ability for the user to adjust things like font size and margins to suit their own personal preferences. For image based books (comics) this is less of an issue as it is the image handling that is now important.
For conversion PDF is also is a bad format as it uses absolute positioning techniques to place both text and images on the pages. This means it reproduces exactly the look the originator intended, but is hard to reverse-engineer back to a format that can support text flow etc.
PDF is fine as a format for which the output is optimised for a device whose screen size is known in advance as then it can be tuned to fit that screen size. If the screen resolution is not known in advance then how well it will perform on the target device tends to eb a function of the software on that device and its ability to resize PDF output.
The advantage of ePub as a format is that even for image files it tends to support a level of resizing of images to fit screens as it is internally a HTML based format. However even here you will get best results for images if the output is generated for a known screen size.
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