I have both a Nook & the Sony 350. I read more with the 350, but I still like my Nook. But I think I'm going to give my Nook to my sister (it is about a year old).
I find the Sony easier to hold & love the touch screen. I did notice smudges on the LCD touch screen for my Nook, but I don't notice them on the new Sony touchscreen. I'm sure they are there but then I do wipe my screens periodically anyway so no problems.
I originally wanted a Sony last year, but wasn't as impressed with the 600 that was being sold at Best Buy. So I got a Nook instead. When the PRS 50s came out & the 350 went on sale for $129 I grabbed one a few months ago. I've been very pleased.
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