Yes!!!! I found the problem. I already tried playing with the firewall settings before because I was assuming, it might be firewall-related. However, disabling didn't solve the problem. Finally, I found a setting in the options of my Desktop Firewall (GData) that seemed to be active even though the firewall is switched off. It was the Web Filter which scans web traffic (content) before it reaches the browser / clients. Once I disabled that filter, things ran smooth. Thanks a lot for your support, Steffen!
P.S. The web filter seems to be implemented using a transparent proxy. Neither IE, nor the debug mode of Calibre shows that proxy.
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