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Thanks for your replies guys, I've checked the permissions on the Calibre folder and I have full control.
Also, I've got some backup software running which monitors file changes and backups up anything that's new or changed, but I've disabled that and still have the same issues.
Possibly the file is set to write only, can you let me know which file I should be looking at?
For info;-
O/S Win 7 x64
Calibre v 0.7.50
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