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Are you using a usb wireless modem. From what you are describing I think your usb port is failing while transferring files. This is just a guess but that is what I think is happening try using a different port if that's true maybe a port behind the pc if you are using the front one
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I think Dopedangel might be on the right track.
But it may not have to be a wireless USB modem. It could just be a flaky USB port and when you plug your Sony or Nook in, it draws enough power to cause things to go flaky.
Along those lines though,it could be the power supply not handling all you have plugged in.
Try connecting to a different USB port, preferably one in a different hub. So, if that port is in the front of your computer plug into a port in the back.
If it still does it, try disconnecting everything USB except your keyboard and mouse and try again.