I loved the Curious Incident, it's really a great book. I also really liked Marcelo in the Real World which is YA about a young man with Aspergers who goes to work at his father's law firm over the summer. Neither of these are anything like Parenthood, though. (and I love Parenthood! Whenever I'm watching it, I wish my sisters were watching it too!). I can't think of a book like it. Tom Perrotta's Little Children (and probably his other books) deals with the experience of parenting but it's much more cynical.
eP
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