People read on smart phones, some of which have screens HALF the size of the 350, so I wouldn't worry about the screen size too much, you will get used to it very quickly.
If you need a larger font for readability, you can bump the font up to the 'M' or even 'L' setting and still have enough words on each line so that the formatting will not be too weird.
With the smaller screen and fewer words per line, it takes very little eye motion to scan a page, and you can fly along reading very quickly.
The only disadvantage to selecting a larger font size is of course that you have to do more page changes to get through the same number of chapters of a book, but page changes are quite quick on the 350 and don't use much battery power.
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