I own a Sony 505 and just got a Nook Color yesterday - before I got my Sony I had a Palm T|X and before that an old Compaq iPaq.
I've read hundreds if not thousands of books on LCD screens (I got the iPaq years before I got my Sony), and a good couple of hundred on EInk. Maybe there's something weird about my eyes, but I can and do read on either technology.
EInk is great for long sessions - it's easy on the eyes and the battery lasts much longer.
The NC is better in low light, and if I'm reading comics or other graphic material.
Given a choice, I'd go with both. (Oh right, I did.)
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