I experience eye strain, too. While I have not personally used the nook color for any length of time, I have used an iPad, iPhone, Nintendo DS, and LCD monitor, and I experience eye strain on all of them.
I currently solve that problem by using computer glasses to help reduce glare.
I do, however, use my iPhone on 50% brightness. Am I correct by inferring from this thread that if I turn the brightness all the way up, I will experience less eye strain? I don't use my computer glasses all the time - only when at home - so it would be nice to solve this problem.
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