I've had my Sony350 a few weeks now. I love the touch page turns (yes sometimes I accidentally turn pages but I was doing that with my Kindle3 all the time too, though not with my Nook).
I also have no difficulty holding it, reading & turning pages. It fits my hands perfectly, but I will admit I don''t have the largest hands.
I am using my Sony more than my other readers, but who knows once the honeymoon is over I will use them all equally...maybe...Did I mention I love my Sony350?