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The issue is that for the most part PDF is not a format that is designed to reflow (unlike HTML for example). In fact, it is designed to make sure that the layout remains constant.
That being said some people have had some success with the latest version of acrobat which does reflow. Try searching this forum and perhaps the irex forum for "reflow" for threads with more info.
You might get somewhere with pdftotext, but that will kill formatting (e.g. italics, bold, titles) and images. There pdfimages tool for extracting images. I've tried with these and other tools on linux but not really ever got anything I was happy with. These days I am happy to use either zoom or rotate single column docs and use the column-wise version of ipdf for multicolumn docs.
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