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ADB (Android Debug Bridge) is basically a way to access the OS command line of your android device from another computer (via USB or wireless connection). It can be helpful for changing settings or troubleshooting your device when things go awry. To use, you need the android SDK (or adb parts of it) on your PC and your Nook also needs to support it.
However, there is almost always another way to do the same thing. Root Explorer (a paid app) can access the system filesystem and change filenames and basic permissions. Terminal emulators can issue command line commands.
Rooting on the Nook is mature enough now that it is rarely needed.
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