To get at the multi-column split features, you click the button with the little magnifying glass (next to Options), and then Page Mode. If you have single-column PDF's to use, try them with Margin Cut (on small to maintain formatting) as well, to see if you feel that makes a difference. I'm currently reading an Epub where using that on small works better than medium (too big).
Good luck, and we'll be interested to see how you do!
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