HarryH, I also have The Grand Design but my file is 10.6 MB, which still is a big file considering the book is like 100 pages long. No doubt, all of the images are inflating the file size beyond what would normally be reasonable. (And the book was massively disappointing so that may color my interpretation of events!)
I have noticed a strange preponderance of huge files when downloading from the Kobo service.
Having said all of this I don't notice any general trends such as a slowing down of the device operations. Some large books (in page count, number of files, or raw file size) do take longer to parse and process and they will be slower.
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