Quote:
Originally Posted by Manichean
You could try and run a disk check.
Also, and this is possibly very stupid, but I just thought of it: You do actually have write privileges in the folder you're creating the empty folder in that your Calibre library should reside in?
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I agree.
Disk I/O error is bad hardware (drive,cable,PSU) or damaged file system

If you have a UBUNTU Live CD handy, boot that and use "disk Utility" to view your drives "S.M.A.R.T. status (the hardware, not the file system)
Using the Live CD does not require making any changes to your system (don't click Install, Nor change any drive partition while peeking)