I enjoy both genre's (and both are often grouped together in bookstores).
I liked someones definition: "Science Fiction is a story showing how some aspect of science or technology affects people or society."
It's broad, general but works for me.
Vampire stories tend to be fantasy, but one story defined a blood-disorder that involved a parasite that took-over the host, improved it (by making it extra strong) but made it damaged by suns rays and require more carbon-based blood to sustain itself - a vampire. This was science fiction because it gave a scientific basis.
But vampires who sparkle - ... i got nothing.
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