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This would not be a simple conversion, but if you're not happy with the direct conversion results Calibre offers you, try exporting to HTML (AFAIK, Acrobat Reader offers that option) and either importing and converting the resulting file to Calibre or using Sigil to create an ePub.
The 25% margin may be a problem requiring some CSS trickery, though- I would suspect that a formatting like that could be badly mangled when changing font sizes, which wouldn't be that uncommon on an ebook reader.
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