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There are no specific studies yet on LCD vs. e-ink and eye strain yet. It's all personal preference. If you can look at an LCD screen for hours and be fine, great. If you can't, great. I personally have bad eyesight and don't like looking at a computer screen for several hours unless the colors are muted and the brightness is turned down. The NC has an option to turn the background to an offwhite or grey back, and you can turn the brightness down.
Personally, until I see a study or I stop spending hours on the computer, I'll use my Nook Wifi. Or at least until I save up the money for a color. :P
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