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I would certainly think so. I wouldn't hesitate to use one myself. It could get rather expensive, though, if you use them often. The microfiber cloths are washable and re-usable. They are also great at wicking up oils and such.
From what I've read, the Kindle's screen is glass (if I'm mistaken about this, please someone let me know), and glass is pretty much immune to any ordinary sort of chemical attack, and impervious to scratching unless a material of similar hardness (sand, dirt, etc.) is rubbed into it. You could just use a paper towel, but it would probably take a lot more rubbing to get rid of a smudge than using a microfiber wipe or an eyeglass-wiper pad would.
Fortunately the Kindle doesn't have a touch-screen so there shouldn't be much smudging going on, unless maybe you've got a cat that likes to lick it.
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