A book using "ſ" will probably have lots of other old (and even inconsistent) spelling. Unless one is willing to bite the bullet and make a fully modernized version[*], I think it's better to keep the old text as is. The main problem is that maybe the font used in the ebook reader (either the default font, or that chosen by the user) does not have the glyph, and it may be annoying for searches; these two reasons can be enough to make someone wish a version with "ſ" replaced with "s".
* Depending on the language, "fully modernized" doesn't necessarily mean the intent, or even the flavour, of the old text is altered.
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