I tried using Mangle to read on a Kindle 3, and while it's readable, it's a little small. However, YMMV. I would suggest going to Best Buy or wherever you can find a Kindle DX and using the web browser to see how a manga page displays, and seeing whether you like it. I don't think there is an 'optimum' size, just a question of how small is too small for you.
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