If this was a comparison between the late PRS-300 versus the PRS-350, I would say that the 300 would be a good choice if you wanted to save some bucks since it is very similar to the PRS-505 I am currently using and am very happy with. But the difference between the PRS-600 and the PRS-650 is huge. The touch screen on the new units work far better than on the previous generation, the lack of glare, the blacker text (which provides better contrast), the better software (The PRS-650 handles ePubs better than the PRS-600), etc.
I recently got my wife the PRS-650 (and inherited her PRS-505) because it addresses all the complaints she had about the PRS-505 (specifically she thought the text was too grey, the unit was too heavy and she didn't like the small buttons; none of which bothers me in the slightest). She likes it quite a bit. I doubt she would have liked the PRS-600.
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Bill
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