I read PDFs a lot on my iPad, because I like the annotation options of iAnnotate better than those on the PRS950 - and I like the bigger screen for graphs and tables.
I probably spend 2-3 hours a day reading academic PDFs. (I read much more than that, but the rest is on my PRS950).
I keep brightness way down, at about 30% and use sepia backgrounds. Even so, eyes do get very tired. And yes, it's heavy.
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