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@Zarathustra, if you want a very usable portable tool to manage PDF as scientific papers and so, the iPad (with GoodReader or iAnnotatePDF) is the perfect tool.
Currently I have in my iPad about 30 GB of papers, all name indexed by GoodReader (they can be searched by name).
You can annotate them and when you take the annotated PDF from iPad to computer the annotations remains into PDF and you can see them in Acrobat Reader or whatever other PDF viewer supporting annotations. And vice-versa.
PDF access is instant, and zooming, cropping, page turning is instantaneously too.
The only two problems I find viewing PDF in iPad is the quality of the fonts (*) and after some hours using the fingers to move around the screen it becomes "blurry" and needs a cleanning. However, sometimes (one in 1000) the apps crashes.
(*) Despite the fact iPad screen has an impressive quality, the font render engine is a big piece of crap that shows fonts with a very low quality compared as it could be shown. A sample can be my iMac, that has the same LED screen: Running Windows the font quality is superior to any other screen I've seen, but running Snow Leopard the fonts sucks.
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