ADB is a necessity for troubleshooting and managing the state of the device. If you encounter problems that could easily be rectified using ADB, you may be forced to reset to factory and re-root to correct the problem.
From NOOK Devs:
http://nookdevs.com/NookColor_USB_ADB
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For users who have failed at implementing the instructions below several times, the NookColor community reccomends that you use market and download adb wireless, and perform your adb work over the wifi connection to the NC rather than painfully trying to install and modify the drivers over and over. If you would prefer to do that in the first place rather than the instructions below, we won't be insulted.
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Someone here commented that they used ADB wireless.